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It should only be used under the care of a licensed provider and from a trusted pharmacy
Without adequate protein intake and resistance training, a significant share of the weight lost on a GLP-1 will be lean mass rather than fat particularly concerning for older adults where sarcopenia is already a risk
A 2022 systematic review and meta-analysis in JAMA Internal Medicine found increased rates of gallbladder or biliary disease among GLP-1 receptor agonist users compared to placebo or active comparators, with higher risk at weight-loss doses
This observation phase provides valuable data about whether adjustments are necessary before making changes
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